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1

Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening

Angeline C.-H. Lee, Pondy Murugappan Ramanujulu, Anders Poulsen, Meredith Williams, Stéphanie Blanchard, Diana M. Ma, Zahid Bonday, Kay Lin Goh, Kee Chuan Goh, Miah Kiat Goh, Jeanette Wood, Brian W. D

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 896 KB

english, 2012

2

Structure-based design of nitrogen-linked macrocyclic kinase inhibitors leading to the clinical candidate SB1317/TG02, a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3)

Anders Poulsen, Anthony William, Stéphanie Blanchard, Harish Nagaraj, Meredith Williams, Haishan Wang, Angeline Lee, Eric Sun, Ee-Ling Teo, Evelyn Tan, Kee Chuan Goh, Brian Dymock

Journal:

Journal of Molecular Modeling

Année:

2013

Langue:

english

Fichier:

PDF, 704 KB

english, 2013

3

Discovery of Kinase Spectrum Selective Macrocycle (16 E )-14-Methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a Potent Inhibitor of Cyclin Dependent Kinases (CDKs), Janus Kinase 2 (JAK2), and Fms-like Tyrosine Kinase-3 (FLT3) for the Treatment of Cancer

William, Anthony D., Lee, Angeline C.-H., Goh, Kee Chuan, Blanchard, Stéphanie, Poulsen, Anders, Teo, Ee Ling, Nagaraj, Harish, Lee, Chai Ping, Wang, Haishan, Williams, Meredith, Sun, Eric T., Hu, Cha

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 1.00 MB

english, 2012

4

PLK1 as a potential drug target in cancer therapy

Kee Chuan Goh, Haishan Wang, Niefang Yu, Yifa Zhou, Yin Zheng, ZeYi Lim, Kanda Sangthongpitag, Lijuan Fang, Mark Du, Xukun Wang, A. B. Jefferson, Janet Rose, Blanche Shamoon, Christoph Reinhard, Brad

Journal:

Drug Development Research

Année:

2004

Langue:

english

Fichier:

PDF, 377 KB

english, 2004

5

Synthesis and evaluation of alkenyl indazoles as selective Aurora kinase inhibitors

Stéphanie Blanchard, Anthony D. William, Angeline C.-H. Lee, Anders Poulsen, Ee Ling Teo, Weiping Deng, Noah Tu, Evelyn Tan, Kay Lin Goh, Wai Chung Ong, Chee Pang Ng, Kee Chuan Goh, Zahid Bonday, Eric

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 2.22 MB

english, 2010

6

N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: Design, synthesis, SAR studies, and in vivo antitumor activity

Haishan Wang, Niefang Yu, Hongyan Song, Dizhong Chen, Yong Zou, Weiping Deng, Pek Ling Lye, Joyce Chang, Melvin Ng, Stéphanie Blanchard, Eric T. Sun, Kanda Sangthongpitag, Xukun Wang, Kee Chuan Goh, X

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 368 KB

english, 2009

7

Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity

Haishan Wang, Ze-Yi Lim, Yan Zhou, Melvin Ng, Ting Lu, Ken Lee, Kanda Sangthongpitag, Kee Chuan Goh, Xukun Wang, Xiaofeng Wu, Hwee Hoon Khng, Siok Kun Goh, Wai Chung Ong, Zahid Bonday, Eric T. Sun

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 396 KB

english, 2010

8

Revised structures for Tü 1718B and valclavam

Jack E. Baldwin, Timothy D.W. Claridge, Goh Kee-Chuan, John W. Keeping, Christopher J. Schofield

Journal:

Tetrahedron Letters

Année:

1993

Langue:

english

Fichier:

PDF, 250 KB

english, 1993

9

Biosynthetic precursors of valclavam

Jack E. Baldwin, Kee-Chuan Goh, Christopher J. Schofield

Journal:

Tetrahedron Letters

Année:

1994

Langue:

english

Fichier:

PDF, 276 KB

english, 1994

10

Enzymes of valclavam biosynthesis

Jack E. Baldwin, Yoshiyuki Fujishima, Kee-Chuan Goh, Christopher J. Schofield

Journal:

Tetrahedron Letters

Année:

1994

Langue:

english

Fichier:

PDF, 251 KB

english, 1994

11

The role of sulphur in cephalosporin biosynthesis

Jack E. Baldwin, Kee-Chuan Goh, Mark E. Wood, Christopher J. Schofield, Robin D.G. Cooper, George W. Huffman

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1991

Langue:

english

Fichier:

PDF, 268 KB

english, 1991

12

Cladosporium cladosporioidesKeratomycosis: A case report

Fiona L. M. Chew, Visvaraja Subrayan, Pei Pei Chong, Meng Chuan Goh, Kee Peng Ng

Journal:

Japanese Journal of Ophthalmology

Année:

2009

Langue:

english

Fichier:

PDF, 201 KB

english, 2009

13

Structure-based design of Aurora A & B inhibitors

Anders Poulsen, Anthony William, Angeline Lee, Stéphanie Blanchard, Eeling Teo, Weiping Deng, Noah Tu, Evelyn Tan, Eric Sun, Kay Lin Goh, Wai Chung Ong, Chee Pang Ng, Kee Chuan Goh, Zahid Bonday

Journal:

Journal of Computer-Aided Molecular Design

Année:

2008

Langue:

english

Fichier:

PDF, 507 KB

english, 2008

14

Regulation of c-myc expression by IFN-γ through Stat1-dependent and -independent pathways

Ramana, Chilakamarti V., Grammatikakis, Nicholas, Chernov, Mikhail, Nguyen, Hannah, Chuan Goh, Kee, Williams, Bryan R.G., Stark, George R.

Journal:

The EMBO Journal

Année:

2000

Langue:

english

Fichier:

PDF, 452 KB

english, 2000

15

Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3)

Anders Poulsen, Anthony William, Stéphanie Blanchard, Angeline Lee, Harish Nagaraj, Haishan Wang, Eeling Teo, Evelyn Tan, Kee Chuan Goh, Brian Dymock

Journal:

Journal of Computer-Aided Molecular Design

Année:

2012

Langue:

english

Fichier:

PDF, 985 KB

english, 2012

16

2-Anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1

Stéphanie Blanchard, Chang Kai Soh, Chai Ping Lee, Anders Poulsen, Zahid Bonday, Kay Lin Goh, Kee Chuan Goh, Miah Kiat Goh, Mohammed Khalid Pasha, Haishan Wang, Meredith Williams, Jeanette M. Wood, Ka

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 2.13 MB

english, 2012

17

SUC1-Associated Neurotrophic Factor Target (SNT) Protein Is a Major FGF-Stimulated Tyrosine Phosphorylated 90-kDa Protein Which Binds to the SH2 Domain of GRB2

Siew Hwa Ong, Kee Chuan Goh, Yoon Pin Lim, Boon Chuan Low, Peter Klint, Lena Claesson-Welsh, Xinmin Cao, Yin Hwee Tan, Graeme R. Guy

Journal:

Biochemical and Biophysical Research Communications

Année:

1996

Langue:

english

Fichier:

PDF, 156 KB

english, 1996

18

Discovery of the Macrocycle 11-(2-Pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a Potent Janus Kinase 2/Fms-Like Tyrosine Kinase-3 (JAK2/FLT3) Inhibitor for the Treatment of Myelofibrosis and Lymphoma

William, Anthony D., Lee, Angeline C.-H., Blanchard, Stéphanie, Poulsen, Anders, Teo, Ee Ling, Nagaraj, Harish, Tan, Evelyn, Chen, Dizhong, Williams, Meredith, Sun, Eric T., Goh, Kee Chuan, Ong, Wai

Journal:

Journal of Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 3.85 MB

english, 2011

19

Discovery of the Macrocycle (9 E )-15-(2-(Pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a Potent Inhibitor of Janus Kinase 2/Fms-LikeTyrosine Kinase-3 (JAK2/FLT3) for the Treatment of Rheumatoid Arthritis

William, Anthony D., Lee, Angeline C.-H., Poulsen, Anders, Goh, Kee Chuan, Madan, Babita, Hart, Stefan, Tan, Evelyn, Wang, Haishan, Nagaraj, Harish, Chen, Dizhong, Lee, Chai Ping, Sun, Eric T., Jayara

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 4.40 MB

english, 2012

20

Structure and Ligand-Based Design of mTOR and PI3-Kinase Inhibitors Leading to the Clinical Candidates VS-5584 (SB2343) and SB2602

Poulsen, Anders, Nagaraj, Harish, Lee, Angeline, Blanchard, Stéphanie, Soh, Chang Kai, Chen, Dizhong, Wang, Haishan, Hart, Stefan, Goh, Kee Chuan, Dymock, Brian, Williams, Meredith

Journal:

Journal of Chemical Information and Modeling

Année:

2014

Langue:

english

Fichier:

PDF, 8.93 MB

english, 2014

21

[IEEE 31st Annual Conference of IEEE Industrial Electronics Society, 2005. IECON 2005. - Raleigh, NC, USA (2005.11.6-2005.11.6)] 31st Annual Conference of IEEE Industrial Electronics Society, 2005. IECON 2005. - Electrode verification and management system for automation of EDM process in mould industry

Hao Zeng,, Beng Siong Lim,, Geok Hong Phua,, Zhongqiang Ding,, Leck Leng Aw,, Toh Khoong Tan,, Xiang Li,, Kiah Mok Goh,, Pin Tat Hee,, Yan Chuan Goh,, Kok Kee Yuen,

Année:

2005

Langue:

english

Fichier:

PDF, 662 KB

english, 2005

22

Preclinical Metabolism and Pharmacokinetics of SB1317 (TG02), a Potent CDK/JAK2/FLT3 Inhibitor

Khalid Pasha, Mohammed, Jayaraman, Ramesh, Pilla Reddy, Venkatesh, Yeo, Pauline, Goh, Evelyn, Williams, Anthony, Chuan Goh, Kee, Kantharaj, Ethirajulu

Journal:

Drug Metabolism Letters

Année:

2012

Langue:

english

Fichier:

PDF, 198 KB

english, 2012

23

Oxidation of deacetylcephalo-sporin C by deacetoxycephalo-sporin C/deacetylcephalosporin C synthase.

BALDWIN, JACK E., GOH, KEE-CHUAN, SCHOFIELD, CHRISTOPHER J.

Journal:

The Journal of Antibiotics

Année:

1992

Langue:

english

Fichier:

PDF, 227 KB

english, 1992

24

AIP Conference Proceedings [Author(s) PROCEEDINGS OF THE 3RD INTERNATIONAL CONFERENCE ON APPLIED SCIENCE AND TECHNOLOGY (ICAST’18) - Penang, Malaysia (10–12 April 2018)] - Flat electroencephalography’s cluster centers movement tracking during epileptic seizure

Mukhni, Syu’aiba, Ken, Tan Lit, Sidik, Nor Azwadi Che, Yong, Goh Chien, Quen, Lee Kee, Liang, Chuan Zun, Asako, Yutaka

Année:

2018

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2018